Thanks all. Some info about how I narrowed it to these two after reviewing itineraries... We are looking at a 7-day one-way cruise. We eliminated Viking because they only have a 10-day option in our timeframe (mid-June to mid-July). While not mentioned, we ruled out Seabourn because it ends in Juneau, leaving us with a long day of travel back home. We also would like to see Glacier Bay or Hubbard, so that rules out Oceania (it also only offers round trip, as mentioned). Silversea has a similar itinerary to Regent, but it stops in Sitka; Regent stops in Icy Strait Point. I'm hearing that Silversea is more formal (we prefer less formal), thus we narrowed the luxury options down to Regent. Holland was recommended by a friend and is still smaller than many (not the luxury lines of course) and we like that it goes to Glacier Bay.
We are very much leaning toward Regent.