drarill
-
Posts
3,874 -
Joined
Content Type
Forums
Store
Blogs
Downloads
Events
Gallery
Posts posted by drarill
-
-
9 minutes ago, markeb said:
That's a clinical trial, so it's not general public (thousands of people, probably).
yes!
-
3 hours ago, UnorigionalName said:
"In the South Africa Phase 2b clinical trial, 60% efficacy (95% CI: 19.9 – 80.1) for the prevention of mild, moderate and severe COVID-19 disease was observed in the 94% of the study population that was HIV-negative."
hmmm.... not a comforting 95% CI
Pfizer and South African variant: https://www.nbcnews.com/news/us-news/pfizer-says-south-african-variant-could-significantly-reduce-vaccine-protection-n1258198
-
7 hours ago, TeeRick said:
A good signal from the lab anyway. My guess (not a fact) is that if the two mRNA vaccines were in trials a bit later and in more countries, after some variants had emerged, their overall efficacy would likely be less than 95%. But probably still very good and still protective for severe cases, hospitalizations and deaths. Pfizer and Moderna have both publicly stated that they are developing variant specific vaccines "just in case".
news about the Novavax trial https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3
-
3
-
-
2 hours ago, TeeRick said:
Here is a nice article published today in the Atlantic. A good read. Talks about the dropping cases in the US, Canada and Europe. And the possible factors for these drops. A bit of overall good news.
https://www.theatlantic.com/ideas/archive/2021/02/why-covid-19-cases-are-falling-so-fast/618041/
Rick, yesterday my son got his second dose on the Novavax trial. He was told that in two months he will get a third shot with the opposite of what he got the first two times, and a fourth shot three weeks after the third. They are doing this with everyone on the trial. I guess this way they keep everyone blinded, but at the same time all the participants know that they are getting the vaccine.
-
7 hours ago, TeeRick said:
Ken in theory the answer to your question is yes. But as an antibody treatment it will be in short supply and very expensive so not sure a ship would carry it unless required to do so. Also requires iv injection and monitoring. Probably better left to hospitals.
About the monoclonal antibodies and the difficulties of administering it https://www.npr.org/sections/health-shots/2021/01/06/953946994/doctors-encouraged-by-antibody-treatments-for-covid-19
-
1
-
-
On 1/13/2021 at 2:05 PM, bikerunner said:
Simple one, just used my dummy twitter account that only have used for these type of things. Otherwise dont use twitter or any of the Social media platforms. Okay i use FB just to get local restaurants menus, mostly the farm to table places. Otherwise yeah this is kind of a pointless one but easy enough.
can you share the link to the offer??
-
6 minutes ago, LGW59 said:
It is free. Trust me I am the ultimate total liberal, but this policy just makes no sense to me.
also it looks like not only Canadians citizens are taking advantage of this "policy" https://www.miamiherald.com/news/nation-world/world/americas/article248347830.html
-
1
-
-
6 hours ago, TeeRick said:
I think the distribution of the vaccine is controlled by CDC and Warp Speed in the US. Everything after that in the hands of the states and counties and cities.
I was more wondering about the dosing and dosing protocols. One dose to more people? A half dose to more people? Versus the current two doses. Who decides? The FDA? HHS? I think this is above a state level decision.
Rick, did you see this? https://news.yahoo.com/moderna-releases-getting-2nd-vaccine-132450965.html
I also have a question; do you think is a good idea to get a serologic test a couple of weeks after the second dose? I have friends that are already doing this, before the second dose🙄, and some are getting IgG+ with IgM- or both of them positives. I didn't want to bother you but I can't find anything about this and will like to read more about this topic.
BTW, my husband received his second Pfizer dose and didn't have any side effects but some of our friends did feel awful for over 24 hrs. This morning (62 hrs post vaccination) he woke up with swollen nodes in his arm, but I think that's a good thing.
Thanks for all your help!!
-
On 12/28/2020 at 12:14 PM, TeeRick said:
The Novavax phase 3 trial for their purified SPIKE protein subunit vaccine is enrolling now.
Rick, a couple of months ago I filled an online form to participate in any COVID vaccine trial. I was called today for the Novavax, but I already received Moderna's on the 24th. Both my children (21 and 23 y/o) will try to get into this trial. Keeping my fingers crossed! I liked that 2/3 will get the actual vaccine on this trial.
https://www.nytimes.com/interactive/2020/health/novavax-covid-19-vaccine.html
-
1
-
-
On 12/30/2020 at 9:49 AM, TeeRick said:
It certainly is an interesting strategy to use only one dose of the AZ/Oxford vaccine in the UK and at least partially protect as many people as possible. This was not part of the clinical trial protocol. But I understand it. For this particular vaccine, the manufacturing and distribution is easier so I think they are counting on that to happen pretty quickly and produce a very large number of doses. If so, the second booster dose will come within a reasonable time. But yikes! no efficacy or safety data to support this strategy so it will make a lot of experts uncomfortable to say the least.
https://www.nytimes.com/2020/12/30/world/europe/uk-covid-19-vaccine-oxford-astrazeneca.html
found this in Twitter...
-
19 hours ago, TeeRick said:
drarill- thank you for these links!
Did you see this?? Russia shipped 300,00 doses of the Sputnik's vaccine to Argentina.
https://www.reuters.com/article/us-health-coronavirus-russia-vaccine-arg-idUSKBN2920XP
-
On 12/29/2020 at 3:32 PM, caymancouple said:
For those wondering about a penicillin allergy and the shot. I just this morning got the Moderna shot, it even said on my paperwork that I was allergic to penicillin and no one said a word.
I'm allergic to shell fish and also got Moderna's on a "drive through" vaccination clinic for MDs and DMDs. Was told to wait 15 min. after the shot if I didn't have any history of allergies and 30 min. if I did have a history of allergies. I had my Epi-Pen ready but didn't need it.
We won't consider any type of traveling before we are fully vaccinated. DH will get his second Pfizer shot next week and I have to wait two more for mine... still, nothing planned right now.
-
9 minutes ago, Fouremco said:
The CDC link doesn't work, at least for me.
try it through the WP https://www.washingtonpost.com/health/2020/12/07/v-safe-tool-covid-vaccine-side-effects/
https://www.kxan.com/news/coronavirus/v-safe-tracking-side-effects-after-the-covid-19-vaccine/
-
18 hours ago, TeeRick said:
UnoriginalName was on target with the post (#1963) explaining the scientific community being very careful about their phrasing on the transmission issue. It was not measured directly in the phase 3 trials reported to date. So scientists and corporations and health care leaders will not say that the vaccines will do something (like prevent transmission) if it was not measured. But importantly that does not at all mean the the vaccines will not or can not prevent transmission. It is just hard to measure definitively in a clinical trial. Especially one designed to just look at efficacy against COVID disease. And this virus is new and a lot continues to be discovered and learned every single day. The general public has come to expect immediate answers but science is a process. The accumulation of data and evidence over time framing the next steps and next questions to be answered. For scientists like myself I can only say that the pace and quality of this vaccine effort since January has been remarkable. The transmission issue in effect will be answered once these vaccines are given to millions of people and the pandemic slowly grinds to a halt.
Good morning! wanted to share two links. One to an interesting article about giving people only one dose of the vaccine and the second one is a link to the CDC V-safe tool, for those of you getting vaccinated.
BTW, I received my first dose of Moderna's vaccine as an early Christmas gift last Thursday. I only experienced soreness on the injection area for two days. My husband will be fully vaccinated in a week because he got Pfizer's vaccine on Dec.17, I will catch up two weeks later 😀
We are experiencing the same frustrations and problems with the vaccine distribution as everywhere else. Though the National Guard is trying to figure out the best way to do this. Wishing all of you a brighter 2021.
https://www.wbur.org/commonhealth/2020/12/18/coronavirus-vaccine-single-dose-debate
https://vsafe.cdc.gov/?fbclid=IwAR3zXYGF3ih5fX4Zp6HtpKEI0SsGh_Sckl9K3FLYTuQG-DwbMBskZc5IjI0
-
1
-
-
9 minutes ago, TeeRick said:
Thanks for the article. I am not sure how often (at least right now with the surge) the front line HC workers will refuse to be vaccinated. But surely that will happen and probably has already happened. The vaccines are a life saving gift for most of us but some will not agree for whatever their reasons are. But then that would be the expected in a free society and their will be corresponding laws and court rulings and lawsuits and mandates and protests and in general a mess. But I will still get my vaccine even if others don't want it. Step aside for those of us who do!
My Facebook feed is full of pictures of doctors and other health care workers getting their vaccines. You can't buy that kind of publicity. I have to admit that watching the first HCW vaccinated here made me cry. Knowing that my husband is already vaccinated gives me peace.
-
2
-
-
On 12/18/2020 at 10:00 AM, TeeRick said:
I guess I wonder what the US and state governments will require for their own government employees beyond military and National Guard? What about State Police? What about the staff in VA hospitals facing elderly veterans on a daily basis? Lots of questions. But I am thinking private institutions like universities might mandate the vaccine for their on campus students. Many already do so for vaccines like meningitis.
Hi Rick, found this article about refusing the vaccine on the healthcare industry, really interesting and raises some good questions at the end. BTW, my husband was vaccinated two days ago and is feeling fine. I hope to get mine soon. https://www.medscape.com/viewarticle/942296
-
5 hours ago, cl.klink said:
They gave me a “COVID-19 vaccination record card,” stating “please keep this record card, which includes medical information about the vaccines you have received.” It included a sticker that indicated the vaccine manufacturer, lot, and expiration date. I presume this is the “evidence” I may need to show one day, or something like it, when society starts to open up some more and requires a kind of proof of vaccine.
Let the process begin, and let’s get sailing again.
- Joel
really happy for you!! can't wait for mine!!!
-
1
-
-
32 minutes ago, TeeRick said:
I do not know specifics and maybe nobody does at this point. So anybody should feel free to move to the next post and not pay any attention to my answer below.
We can maybe assume they are concerned about anaphylaxis since they talk about those people carrying epipens should avoid the vaccine for now.
Some ideas (from me) for what it's worth. I do not have anything but speculation to offer.
The Pfizer vaccine like any other vaccine could stimulate a heightened but non-specific immune response leading to anaphylaxis in those prone to it.
1)The Pfizer vaccine formulation is mRNA with a lipid coating.
It is hard to imagine that mRNA per se would be the allergen since every cell in our bodies produce it continuously. But a couple of things to consider. The mRNA in the vaccine was made with slightly different chemical base modifications to enhance its stability once injected. Also mRNA can fold itself into different unique structures depending on its sequence. Either might make it look like a foreign antigen in some of the highly susceptible people.
2)The lipid +mRNA complex could be viewed as a foreign antigen. Also the lipid coating itself.
3)Other components of the vaccine formulation mixture - but not sure what else is in it. Vaccine formulation scientists have great knowledge from other vaccines about safe and inert components to use so this is probably not the source of the reactions. Unless something new and untried was required for the mRNA-lipid complex.
Thanks Rick! I really appreciate your input. I come to this thread almost every day to check everyone's opinions. All of you have make my research easier. We also received our first doses today and hope this means the beginning of the end.
have a great day!!
Lydia
-
27 minutes ago, TeeRick said:
This is such a great point. All of the folks in hospitals that are hugely responsible for keeping everything working smoothly behind the scenes are very important and also at risk. Hopefully they all will get vaccinated early on.
Same here in Puerto Rico, I really hope my husband gets the vaccine soon. I'm a dentist and although we are high risk, the truth is that our strict protocols are working and I can wait.
Rick, do you have more information about the allergies reported in the UK? Do you have any idea about the component of the vaccine that might trigger these allergic reactions? I will appreciate any information you can share with us.
-
18 hours ago, terrydtx said:
I can see this being a requirement to get on any cruise ship along with rapid testing before boarding for 2021 and 2022. Additionally I can see, once a vaccine is available most International airlines and destinations may have the same requirements.
Agreed, and Quantas already announced that they will require the vaccine in the future.https://www.bbc.com/news/amp/world-australia-55048438
-
1 hour ago, TeeRick said:
Hopefully everybody has seen the early news of the Pfizer vaccine efficacy (90% interim look). Great news! Great positive day for the world. Hopefully no future curve balls and the data hold throughout the trial But a huge first step. Pfizer press release below.
Great News!!!👏👏
-
1
-
-
-
1 hour ago, TeeRick said:
OK this is a very interesting topic (MMR vaccine and COVID) that I have been following. Initially I thought no way - but I am now thinking there might be something to it.
1) The group at Washington University St Louis is a very good medical team coordinating the 30,000 person trial.
2) Most of us have had the MMR vaccine in early childhood and it offers T-Cell based protection against those 3 viruses (mixture of 3 live attenuated viruses). It also offers some neutralizing antibody protection for years (20?) but we lose it later in life.
3) It seems that 30 AA residues share similarities between the Spike (S) of the SARS-CoV-2 virus and the Fusion glycoprotein of Measles virus and the envelope glycoprotein of the Rubella virus. This might provide protective T-Cell epitopes and antibodies.
4) Boosting with MMR as an adult might be a general boost to the immune system helping protect against COVID.
5) Some interesting points to consider: why are our kids mostly protected from COVID disease even if positive for the virus? And younger people in general? Perhaps because they have "fresher" immunity from more recent MMR vaccinations vs older adults?
6) The case of the USS Roosevelt is quite interesting. The US Navy gave all sailors a booster MMR vaccine. It was reported that 955 sailors were positive for the virus but only 1 hospitalized. Interesting!
I am open-minded on this approach and am considering getting an MMR booster myself. It is safe and can't hurt.
There are similar studies with the BCG vaccine and protection against COVID in those countries (not US) that use it.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413058/
Thanks Rick! already have an appointment for my booster this Friday. Hope the researchers are checking if those children that are getting sick were immunized or not.
-
3 hours ago, TeeRick said:
The US does not fund WHO under the current administration as of a few months ago. China is developing their own vaccine and own program.
Rick, do you mind if I pick your mind? What do you think about this? Been reading about COVID and the MMR vaccine. I also have colleagues getting a booster.
Are vaccines the light at the end of the tunnel?
in Celebrity Cruises
Posted
https://www.wsj.com/articles/first-free-covid-vaccines-from-who-backed-covax-arrive-in-ghana-11614155319