Well, the Eliza Jane is a great location in the Central Business District, which is a short walk from the French Quarter. The Saint is on Canal Street on the French Quarter side. It is also a bit high up, with more of the restaurants, etc... toward the river. I have not stayed in either, but if those were my choices, I would choose the Eliza Jane for location and amenities around it. The Eliza Jane should also be quieter because it is not directly next to the French Quarter (although the Saint is two blocks north of Bourbon, which should make it quieter).